Marijuana

Marijuana

Medically reviewed byGiorgi (Guga) Sikharulidze · Professor of Psychiatry, MD,PhD · Founder & Clinical Director· Last updated: July 7, 2026

The active substance in cannabis, THC (Delta-9-tetrahydrocannabinol), affects brain neurons and their receptors, which impacts concentration, memory, cognitive functions, coordination, and changes in behavior control.

Marijuana use disrupts mental well-being.

Signs of addiction include:

  • Increased tolerance, inability to achieve the usual high
  • Irresistible craving
  • Long time spent obtaining and using the drug
  • Continuous use despite problems created
  • Difficulties in fulfilling responsibilities (interpersonal relationships, academic performance, job responsibilities), which contributes to self-critical thoughts and anxiety
  • Decreased self-esteem
  • Unsuccessful attempts to quit use independently

Withdrawal symptoms include:

  • Irritability
  • Anxiety
  • Sleep disturbances
  • Mood swings
  • Reduced enthusiasm and energy
  • Paranoia
  • Psychosis
  • Exacerbation of neurotic conditions

Along with the desire to overcome addiction, maintaining a stable mental state and minimizing factors leading to relapse are essential.

Closely related to mental health problems such as:

  • Depression
  • Anxiety disorders
  • Cognitive dysfunction
  • Increased risk of suicide
  • Psychosis... [1]

References

1. Marconi A, Di Forti M, Lewis CM, Murray RM, Vassos E. Meta-analysis of the Association Between the Level of Cannabis Use and Risk of Psychosis. Schizophr Bull. 2016;42(5):1262–1269. doi:10.1093/schbul/sbw003

Source: NIDA — Cannabis.

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